Jifu Wei, Editor, Global Journal of Immunology

Ji-Fu Wei, Ph.D.
Director and Professor
Research Division of Clinical Pharmacology
The First Affiliated Hospital
Nanjing Medical University
Nanjing, China

 Honor:  

In 2006, the second prize in Science and technology progress award of Shantou City, Guangdong Province, China

In 2008, the third prize in Science and technology progress award of Guangdong Province, China

Education:

Anhui University, China    1993-1997       B.S. Biochemistry and Molecular Biology

Kunming institute of zoology, CAS       1998-2003       Ph.D. Biochemistry

Work experience:

2011 – present, Professor, The First Affiliated Hospital of Nanjing Medical University, Research Division of Clinical Pharmacology

2007 to 2011, Associate Professor, The First Affiliated Hospital of Nanjing Medical University, Clinical Central Laboratory

2006 to 2007, Assistant Research Fellow, The First Affiliated Hospital of Nanjing Medical University, Clinical Central Laboratory

2003 – 2005, Postdoctoral Fellow, Shantou University, China

Selected publication:

First and co-first author:

  1. An S, Ma D, Wei JF, Yang X, Yang HW, Yang H, Xu X, He S, Lai R.A novel allergen Tab y 1 with inhibitory activity of platelet aggregation from salivary glands of Allergy. 2011. Nov; 66 (11):1420-7.
  2. Wei J F, Xu T R, Yu M C, et al. Protein Drugs Related to Allergic Reaction. Biomed Research International, 2015, 2015:1-2.
  3. Wei J F, Wang Y Q, Luo H R. Drug-Related Genomics in Cancer and Immunological Diseases. International Journal of Plant Genomics, 2014, 2014(2):306980.
  4. Wei J F. Preparation and identification of Per a 5 as a novel American cockroach allergen. Mediators of Inflammation, 2014, 2014(6):591468.
  5. Wei JF, Wei XL, Chen QY, Huang T, Qiao LY, Wang WY, Xiong YL, He SH.N49 phospholipase A2, a unique subgroup of snake venom group II phospholipase A2.Biochim Biophys Acta. Mar;1760(3):462-71.
  6. Wei JF, Mo YZ, Qiao LY, Wei XL, Chen HQ, Xie H, Fu YL, Wang WY, Xiong YL, He SH.Potent histamine-releasing activity of atrahagin, a novel snake venom metalloproteinase.Int J Biochem Cell Biol.2006.38(4):510-20.
  7. An S, Chen L, Wei JF, Yang X, Ma D, Xu X, Xu X, He S, Lu J, Lai R.Purification and characterization of two new allergens from the venom of Vespa magnifica.PLoS One. 7(2):e31920.
  8. Zhang CY, Wei JF, He SH.Adaptive evolution of the spike gene of SARS coronavirus: changes in positively selected sites in different epidemic groups.BMC Microbiol.2006.Oct 4;6:88.
  9. Wei JF, Li T, Wei XL, Sun QY, Yang FM, Chen QY, Wang WY, Xiong YL, He SH.Purification, characterization and cytokine release function of a novel Arg-49 phospholipase A(2) from the venom of Protobothrops mucrosquamatus.Biochimie.2006.Oct;88(10):1331-42.
  10. Wei JF, Wei XL, Mo YZ, He SH.Induction of mast cell accumulation, histamine release and skin edema by N49 phospholipase A2.BMC Immunol.2009.Apr 28;10:21.
  11. Wei JF, Wei XL, Chen QY, He SH.Induction of inflammatory cell accumulation by TM-N49 and promutoxin, two novel phospholipase A(2).Toxicon.2010.Sep 15;56(4):580-8.
  12. Wei JF, Wei XL, Mo YZ, He SH.Induction of microvascular leakage and histamine release by promutoxin, an Arg49 phospholipase A2.Toxicon.2010.Apr 1;55(4):888-96.
  13. Wei JF, Yang HW, Wei XL, Qiao LY, Wang WY, He SH.Purification, characterization and biological activities of the L-amino acid oxidase from Bungarus fasciatus snake venom.Toxicon.2009.Sep 1;54(3):262-71.
  14. Wei XL, Wei JF, Li T, Qiao LY, Liu YL, Huang T, He SH.Purification, characterization and potent lung lesion activity of an L-amino acid oxidase from Agkistrodon blomhoffii ussurensis snake venom.Toxicon.2007.Dec 15;50(8):1126-39.
  15. Wei JF, Wei XL, Mo YZ, Yang H, He SInduction of mast-cell accumulation by promutoxin, an arg-49 phospholipase A2.Biomed Res Int.2013.2013:206061
  16. Wei JF, Lü QM, Jin Y, Li DS, Xiong YL, Wang WY.Alpha-neurotoxins of Naja atra and Naja kaouthia snakes in different regions.ACTA BIOCH BIOPH SIN2003.Aug;35(8):683-8.
  17. Wei JF, Wei Q, Lu QM, Tai H, Jin Y Wang, WY, Xiong YL.Purification, characterization and biological activity of an L-amino acid oxidase from Trimeresurus mucrosquamatus venom.ACTA BIOCH BIOPH SIN2003.Mar;35(3):219-24.
  18. Zhang CY, Wei JF, Wu JS, Xu WR, Sun X, He SH.Evaluation of FORS-D analysis: a comparison with the statistically significant stem-loop potential.Biochem Genet.2008.Feb;46(1-2):29-40.
  19. Zhang CY, Wei JF, He SH.The key role for local base order in the generation of multiple forms of China HIV-1 B’/C intersubtype recombinants.BMC Evol Biol.2005.Oct 7;5:53.
  20. Zhang CY, Wei JF, Het SH.Local base order influences the origin of ccr5 deletions mediated by DNA slip replication.Biochem Genet.2005.Jun;43(5-6):229-37.
  21. Wei JF, Wei XL, Mo YZ, et al. Induction of mast-cell accumulation by promutoxin, an Arg-49 phospholipase A2. Biomed Research International, 2013, 2013(2013):206061.

*Corresponding author:

  1. Li X X, Shi L, Zhou X J, Wei JF*, Ding Q*. The role of c-Myc-RBM38 loop in the growth suppression in breast cancer.Journal of Experimental & Clinical Cancer Research, 2017, 36(1):49.
  2. Hu Y, Yang L, Yang H, Wei JF*. Identification of snake venom allergens by two-dimensional electrophoresis followed by immunoblotting. Toxicon, 2016, 125.
  3. Yang ZC, Yu F, Wang YQ, Wei JF*. Stereoselective Pharmacodynamics and Pharmacokinetics of Proton Pump Inhibitors. Current Drug Metabolism, 2016, 17(999).
  4. Jin M, Yang H W, Tao A L, Wei JF*. Evolution of the protease-activated receptor family in vertebrates. International Journal of Molecular Medicine, 2016, 37(3):593-602.
  5. Fu YY, Chen Q, Ji CM,Wei JF*.CYP2E1 RsaI polymorphism and susceptibility of gastrointestinal cancers: A meta-analysis of 35 case-control studies. Int J Clin Exp Med, 2016;9(2):2666-2676.
  6. Cheng G, Ji C, Yang N, Meng L, Wei J*. RNA-binding protein RBM38: acting as a tumor suppressor in colorectal cancer.Int J Clin Exp Med 2016;9(4):7115-7126.
  7. Zhou Y, Ji C, Cao M, Wei J*. Inhibitors targeting the SUMOylation pathway: A Patent Review 2012-2015. 2016
  8. Tong X, Guo M, Jin M, Wei J*. In silico epitope prediction, expression and functional analysis of Per a 10 allergen from the American cockroach.International Journal of Molecular Medicine, 2016.
  9. Yang H, Chen H, Jin M, Wei J*.Molecular cloning, expression, IgE binding activities and in silico epitope prediction of Per a 9 allergens of the American cockroach. International Journal of Molecular Medicine, 2016, 38(6):1795-1805.
  10. Yang H, Yang L, Wang D, Wei J*. Anaphylactic shock caused by haemocoagulase injection in China.2016
  11. Lou P, Li C, Liang S, Wei J*.RNPC1 enhances progesterone receptor functions by regulating its mRNA stability in breast cancer. 2016.
  12. Yang Y, An S, Liu Y, Wei J*.Novel serotonin receptor 2 (5-HT2R) agonists and antagonists: a patent review (2004-2014). Expert Opinion on Therapeutic Patents, 2016, 26(1):89.
  13. Shi L, Xia T S, Wei X L, Wei J*.Estrogen receptor (ER) was regulated by RNPC1 stabilizing mRNA in ER positive breast cancer. Oncotarget, 2015, 6(14):12264-12278.
  14. Cheng Y, Xiao Y, Deng X, Wei J*.Metabolomics in bladder cancer: a systematic review. International Journal of Clinical & Experimental Medicine, 2015, 8(7):11052-11063.
  15. Yuan H Y, Zhang X L, Zhang X H, Wei J*. Analysis of patents on anti-rheumatoid arthritis therapies issued in China. Expert Opinion on Therapeutic Patents, 2015, 25(8):909.
  16. Li X, Yang H W, Chen H, Wei JF*.  In Silico Prediction of T and B Cell Epitopes of Der f 25 in Dermatophagoides farinae. International Journal of Plant Genomics, 2014, 2014(2):483905.
  17. Chen H, Jin M, Wang Y F, Wei JF*. Effect of Toona microcarpa Harms leaf extract on the coagulation system. Biomed Research International, 2014, 2014(13):615363.
  18. Xie J X, Wei J F*, Meng L. Teicoplanin-induced hepatocellular liver injury: a case report and literature review of 17 cases in mainland China. International Journal of Clinical Pharmacology & Therapeutics, 2014, 52(6):525.
  19. Chen H, Yang H W, Wei J F*. In silico prediction of the T-cell and IgE-binding epitopes of Per a 6 and Bla g 6 allergens in cockroaches. Molecular Medicine Reports, 2014, 10(4):2130.
  20. Kong Y, Chen H, Wang Y Q, Wei J F*. Direct thrombin inhibitors: patents 2002-2012 (Review). Molecular Medicine Reports, 2014, 9(5):1506-1514.
  21. Yuan H Y, Zhang X H, Zhang X L,Wei J F*. Analysis of patents on anti-gout therapies issued in China. Expert Opinion on Therapeutic Patents, 2014, 24(5):555-572.
  22. Kong Y, Shao Y, Chen H, Ming X, Wang JB, Li ZY, Wei JF*. A Novel FactorXa-Inhibiting Peptide from Centipedes Venom. Int J Pept Res Ther. 2013;19:303-311.
  23. Xie JX, Wei JF*, Meng L. Montelukast sodium-induced hematuria: a case reportand literature review of 19 cases in mainland China. Int J Clin Pharmacol Ther.2013 Dec;51(12):958-62.
  24. Zhai RR, Jiang AP, Wang HB, Ma L, Ren XX, Jiang JF, Wu L, Wei JF*, Wang JH. Histamine enhances HIV-1-induced modulation of dendritic cells to skew naïve Tcell differentiation toward regulatory T cells. Virology. 2013 Aug 1;442(2):163-72.
  25. Li H, Meng L, Liu F, Wei JF*, Wang YQ.H+/K+-ATPase inhibitors: a patent review.Expert Opin Ther Pat.2013.Jan;23(1):99-111
  26. Kong Y, Huang SL, Shao Y, Li S, Wei JF*.Purification and characterization of a novel antithrombotic peptide from Scolopendra subspinipes mutilans.J Ethnopharmacol.2013.Jan 9;145(1):182-6.
  27. Wang Y, Yang H, Wei JF*, Meng L.Efficacy and toxicity of capecitabine-based chemotherapy in patients with metastatic or advanced breast cancer: results from ten randomized trials.Curr Med Res Opin.2012.Dec;28(12):1911-9
  28. Yang L, Luo Y, Wei J*.Integrative genomic analyses on Ikaros and its expression related to solid cancer prognosis.Oncol Rep.2010.Aug;24(2):571-7.
  29. Yang L, Luo Y, Wei J*, He S.Integrative genomic analyses on IL28RA, the common receptor of interferon-lambda1, -lambda2 and -lambda3.Int J Mol Med.2010.May;25(5):807-12.
  30. Yang L, Wei J*, He S.Integrative genomic analyses on interferon-lambdas and their roles in cancer prediction.Int J Mol Med.2010.Feb;25(2):299-304.
  31. Yang L, Luo Y, Wei J*, Ren C, Zhou X, He S. Methods for protein identification using expressed sequence tags and peptide mass fingerprinting for seed crops without complete genome sequences. Seed Sci Res 2010.20(4): 257-262.

Co-author:

  1. Yang H, Li T, Wei J, Zhang H. He S. Induction of Tumor Necrosis Factor (TNF) Release from Subtypes of T Cells by Agonists of Proteinase Activated Receptors. Mediators Inflamm. Epub 2013 Dec 16.2013:165453.
  2. Yang H, Kong X, Wei J, Liu C, Song W, Zhang W, Wei W, He S. Cockroach allergen Per a 7 down-regulates expression of Toll-like receptor 9 and IL-12 release from P815 cells through PI3K and MAPK signaling pathways.Cell Physiol Biochem.2012.29(3-4):561-70.
  3. Li SK, Leung RK, Guo HX, Wei JF, Wang JH, Kwong KT, Lee SS, Zhang C, Tsui SK.Detection and identification of plasma bacterial and viral elements in HIV/AIDS patients in comparison to healthy adults.Clin Microbiol Infect.2012.Nov;18(11):1126-33.
  4. Tian RR, Guo HX, Wei JF, Yang CK, He SH, Wang JH.IFN-λ inhibits HIV-1 integration and post-transcriptional events in vitro, but there is only limited in vivo repression of viral production.Antiviral Res.2012.Jul;95(1):57-65.
  5. Yang H, Wei J, Zhang H, Song W, Wei W, Zhang L, Qian K, He S. Upregulation of  Toll-like Receptor (TLR) expression and release of cytokines from mast cells by IL-12.Cell Physiol Biochem.2010.26(3):337-46.
  6. He S, Zhang Z, Zhang H, Wei J, Yang L, Yang H, Sun W, Zeng X, Yang P. Analysis of properties and proinflammatory functions of cockroach allergens Per a 1.01s.Scand J Immunol.2011.Sep;74(3):288-95.
  7. Zhang S, Zeng X, Wei J, Li S, He S.Analysis of trends and opportunities of anti-allergy patents in China from 1998 to 2008. Recent Pat Inflamm Allergy Drug Discov2010.4(2):130-7
  8. Hua HY, Liang YS, Zhang Y, Wei JF, Guo HX.The sensitivity of artesunate against Schistosoma japonicum decreased after 10 years of use in China. Parasitol Res.2010.Sep;107(4):873-8.
  9. Zhang S, Zeng X, Wei J, Li S, He S. Analysis of patents on anti-allergic therapies issued in China from 1988 to 2008. Expert Opin Ther Pat. 2010.Jun;20(6):727-37.
  10. Guo D, Ding N, Xu Y, Guo H, Wei JF, Wang JH, He G, Yang R, Zhang C.Near full-length genome characterization of an HIV-1 CRF01_AE strain in Jiangsu, China: evidence of two independent introductions from Fujian.AIDS Res Hum Retroviruses.2009.Jun;25(6):619-23.
  11. Yang H, Wei J, Zhang H, Lin L, Zhang W, He S.Upregulation of Toll-like receptor (TLR) expression and release of cytokines from P815 mast cells by GM-CSF. BMC Cell Biol.2009.May 9;10:37.
  12. Guo H, Guo D, Wei JF, Yang H, Huan X, Tsui SK, Yang R, Zhang C.First detection of a novel HIV Type 1 CRF01_AE/07_BC recombinant among an epidemiologically linked cohort of IDUs in Jiangsu, China.AIDS Res Hum Retroviruses.2009.Apr;25(4):463-7.
  13. Guo H, Wei JF, Yang H, Huan X, Tsui SK, Zhang C.Rapidly increasing prevalence of HIV and syphilis and HIV-1 subtype characterization among men who have sex with men in Jiangsu, China.Sex Transm Dis.2009.Feb;36(2):120-5.
  14. Zhang C, Ding N, Wei JF.Different sliding window sizes and inappropriate subtype references result in discordant mosaic maps and breakpoint locations of HIV-1 CRFs.Infect Genet Evol.2008.Sep;8(5):693-7.
  15. Zhang C, Xu S, Wei JF, Forsdyke DR.Microsatellites that violate Chargaff’s second parity rule have base order-dependent asymmetries in the folding energies of complementary DNA strands and may not drive speciation.J Theor Biol.2008.Sep 7;254(1):168-77.
  16. Lu QM, Wei Q, Jin Y, Wei JF, Wang WY, Xiong YL.L-amino acid oxidase from Trimeresurus jerdonii snake venom: purification, characterization, platelet aggregation-inducing and antibacterial effects.J Nat Toxins.2002.Dec;11(4):345-52.
  17. Wei Q, Jin Y, Lu QM, Wei JF, Wang WY, Xiong YL.Purification and characterization of alpha-mucrofibrase, a novel serine protease with alpha-fibrinogenase activity from the venom of Chinese Habu (Trimeresurus mucrosquamatus).J Nat Toxins.2002.Dec;11(4):337-43.
  18. Wei Q, Lu QM, Jin Y, Li R, Wei JF, Wang WY, Xiong YL.Purification and cloning of a novel C-type lectin-like protein with platelet aggregation activity from Trimeresurus mucrosquamatus venom.Toxicon.2002.Sep;40(9):1331-8.
  19. Lu QM, Jin Y, Wei JF, Li DS, Zhu SW, Wang WY, Xiong YL.Characterization and cloning of a novel phospholipase A(2) from the venom of Trimeresurus jerdonii snake. 2002. Sep;40(9):1313-9.
  20. Meng QX, Wang WY, Lu QM, Jin Y, Wei JF, Zhu SW, Xiong YL.A novel short neurotoxin, cobrotoxin c, from monocellate cobra (Naja kaouthia) venom: isolation and purification, primary and secondary structure determination, and tertiary structure modeling.Comp Biochem Physiol C Toxicol Pharmacol.2002.May;132(1):113-21.
  21. Lu QM, Jin Y, Wei JF, Wang WY, Xiong YL.Biochemical and biological properties of Trimeresurus jerdonii venom and characterization of a platelet aggregation-inhibiting acidic phospholipase A2.J Nat Toxins.2002.Feb;11(1):25-33.
  22. Jin Y, Lu QM, Wei JF, Li DS, Wang WY, Xiong YL.Purification and characterization of jerdofibrase, a serine protease from the venom of Trimeresurus jerdonii snake.Toxicon.2001.Aug;39(8):1203-10.

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