Yu Sun, Editor, Global Journal of Immunology

Yu Sun, Ph.D.
Professor and Principal Investigator
Expert of National 1000-Talents Program of China
Shanghai Institutes for Biological Sciences
Chinese Academy of Sciences
Shanghai, China

 Honor

Expert of National 1000 Talents Program of China

 Education

Dalhousie University, Canada, 2000-2005, Ph. D

Chinese Academy of Sciences, 1996-1999, MSc

Yantai University, 1992-1996, BSc

 Work experience: 

Postdoctoral fellow, University of British Columbia, 2005-2006

Postdoctoral fellow, Fred Hutchinson Cancer Research Center, 2006-2011

Staff Scientist, Fred Hutchinson Cancer Research Center, 2011-2012

Assistant Professor (PI), University of Washington, 2012-2014

Professor, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 2014-present

Selected publication

  1. Han, L., Xu, J., Xu, Q., Zhang, B., Lam, E. W. -F. and Sun, Y. Extracellular vesicles in the tumor microenvironment: therapeutic resistance, clinical biomarkers and targeting strategies. Med. Res. Rev.DOI: 10.1002/med.21453.
  2. Gomez-Sarosi, L., Sun, Y.,Coleman I, Bianchi-Frias D, Nelson PS. 2017. DNA Damage Induces a Secretory Program in the Quiescent TME that Fosters Adverse Cancer Phenotypes. Mol Cancer Res. 15: 842-851.
  3. Sun, Y. Tumor Microenvironment and Cancer Therapy Resistance. Cancer Lett.380: 205–215.
  4. Xu, Q.,Chiao, P. and Sun, Y.  Amphiregulin in cancer: new insights for translational medicine. Trends in Cancer. 2: 111-113.
  5. Sun, Y., Zhu, D., Chen, F.,Qian, M., Wei, H., Chen, W. and Xu, J. 2016. SFRP2 augments WNT16B signaling to promote therapeutic resistance in the damaged tumor microenvironment. Oncogene. 35: 4321-4334.
  6. Zhang, B. and Sun, Y. Landscape and Targeting of the Angpt-Tie System in Current Anticancer Therapy. Transl Med. 5: 157. doi:10.4172/2161-1025.1000157.
  7. Laberge, R. M., Sun, Y.,Orjalo, A. V., Patil, C. K., Freund, A., Zhou, L., Curran, S. C., Davalos, A. R., Wilson-Edell, K. A., Liu, S., Limbad, C., Demaria, M., Li, P., Hubbard, G. B., Ikeno, Y., Javors, M., Desprez, P. Y., Benz, C. C., Kapahi, P., Nelson, P. S. and Campisi, J. mTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation. Nat. Cell. Biol. 17: 1049-1061.
  8. Chen, F., Zhuang, X., Lin, L., Yu, P., Wang, Y., Shi, Y., Hu, and Sun, Y. 2015. New Horizons in the Tumor Microenvironment Biology: Challenges and Opportunities. BMC Medicine. 13: 45. (highly accessed and journal-featured article)
  9. Sun, Y. Translational Horizons in the Tumor Microenvironment: Harnessing Breakthroughs and Targeting Cures. Med. Res. Rev.35: 408-436. (cover page article)
  10. Chen, F., Qi, X., Qian, M., Dai, Y. and Sun, Y. Tackling the Tumor Microenvironment: What Challenge Does It Pose to Anticancer Therapies? Protein Cell.5: 816–826.
  11. Sun, Y., Campisi, J., Higano, C., Beer, T. M., Porter, P., Coleman, I., True, andNelson, P. S. 2012. Treatment-Induced Damage to the Tumor Microenvironment Promotes Prostate Cancer Therapy Resistance through WNT16B. Nat. Med. 18: 1359-1368. (Article featured by the journal, highlighted by Nature, reviewed by Cancer Discovery, Nature, Nature Medicine, and Nature Reviews Clinical Oncology)
  12. Sun, Y.and Nelson, P. S. 2012. Molecular Pathways: Involving Microenvironment Damage Responses in Cancer Therapy Resistance. Clin Cancer Res. 18: 4019-4025.
  13. Bluemn, E. G., Paulson, K. G., Higgins, E. E., Sun, Y., Nghiem, P. and Nelson, P. S. 2009. Merkel Cell Polyomavirus is not Detected in Prostate Cancers, Surrounding Stroma, or Benign Prostate Controls. J Clinical Virology. 44: 164-166.
  14. Coppé, J. -P., Patil, C. K., Rodier, F., Sun, Y., Muñoz, D. P., Goldstein, J., Nelson, P. S., Desprez, P. –Y., and Campisi, J.  2008. Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor.PloS Biology. 6: 2853-2868.
  15. Sun, Y., Wong, N., Guan, Y., Salamanca, C. M., Cheng, J. C., Lee, J. M., Gray, J. W., and Auersperg, N. 2008. The Eukaryotic Translation Elongation Factor eEF1A2 Induces Neoplastic Properties and Mediates Tumorigenic Effects of ZNF217 in Precursor Cells of Human Ovarian Carcinomas. Int J Cancer. 123: 1761-1769.
  16. Li, P., Maines-Bandiera, S., Kuo, W., Guan, Y., Sun, Y., Hills, M., Huang, G., Collins, C. C., Leung, P. C. K., Gray, J. W. and Auersperg, N. 2007. Multiple Roles of the Candidate Oncogene ZNF217 in Ovarian Epithelial Neoplastic Progression. Int J Cancer. 120:1863-1873.
  17. Sun, Y., Bojikova-Fournier, S. and MacRae, T. H. Structural and Functional Roles for β-Strand 7 in the α-Crystallin Domain of p26, a Poly-disperse Small Heat Shock Protein from the Extremophile, Artemia franciscana. FEBS J. 273: 1020-1034.
  18. Villeneuve, T. S., Ma, X., Sun, Y., Oulton, M. M., Oliver, A. E. and MacRae, T. H. 2006. Inhibition of Apoptosis by p26: Implications for Small Heat Shock Protein Function during Artemia Cell Stress & Chaperones.11: 71-80.
  19. Ma, X., Jamil, K., MacRae, T. H., Clegg, J. S, Russell, J. M., Villeneuve, T. S., Euloth, M., Sun, Y., Crowe, J. H., Tablin, F. and Oliver, A. E. 2005. A Small Stress Protein Acts Synergistically with Trehalose to Confer Desiccation Tolerance on Mammalian Cells. Cryobiology.51: 15-28.
  20. Sun, Y.and MacRae, T. H. 2005. Characterization of Novel Sequence Motifs within Amino- and Carboxy-Terminal Extensions of p26, a Small Heat Shock Protein from Artemia franciscana. FEBS J. 272: 5230-5243.
  21. Sun, Y.and MacRae, T. H. 2005. Small Heat Shock Proteins: Molecular Structure and Chaperone Function. Cell Mol. Life Sci. 62: 2460-2476.
  22. Sun, Y.and MacRae, T. H. 2005. The Small Heat Shock Proteins and their Role in Human Disease. FEBS J. 272: 2613-2627.
  23. Sun, Y., Mansour, M., Crack, J. A., Gass, G. L. and MacRae, T. H. 2004. Oligomerization, Chaperone Activity and Nuclear Localization of p26, a Small Heat Shock Protein from Artemia franciscana. Biol. Chem.279: 39999-40006.