Zhengde Xie, Editor, Global Journal of Immunology

Zhengde Xie, MD
Research Professor and Associate Chief Physician
Director, Virology Laboratory
Beijing Pediatric Research Institute
Beijing Children’s Hospital
Capital Medical University
China

Education:

  1. July, 2007. MD of pediatrics, Capital Medical University;
  2. July, 2002. Clinical master of pediatrics, Capital Medical University;
  3. July, 1991. Graduated from Tongji University of Medical Sciences, majored in pediatrics.

Work experience:

  1. January, 2003~: Research Professor, Associate Chief Physician, Director of Virology Lab, Beijing Chindren’s Hospital,Capital Medical University;
  2. April, 2002~January, 2003: Attending pediatrician, VirologyLab, Beijing Chindren’s Hospital,  Capital Medical University;
  3. January, 1997~March, 2002: Attending pediatrician in Xuanwu Hospital;
  4. July, 1991~October, 1996: Resident of pediatrics in Xuanwu Hospital, Capital Medical University.

Selected publication:

  1. Chen XP, Sun SZ, Guo JY, Li JJ,Xie ZD. Complete Genome Sequence Analysis of Echovirus 18 Associated with Aseptic Meningitis in Hebei Province, China, in 2015. Genome Announc. 2016 Oct 27;4(5). pii: e01165-16. doi: 10.1128/genomeA.01165-16.
  2. Gao L,  Ai J,  Xie Z,  Zhou C,  Liu C,  Zhang H,  Shen K. Dynamic expression of viral and cellular microRNAs in infectious mononucleosis caused by primary Epstein-Barr virus infection in children. Virol J. 2015 Dec 3;12(1):208. doi: 10.1186/s12985-015-0441-y.
  3. Wang Y, Ai J, Xie Z, Qin Q, Wu L, Liu Y, Liu C, Shen K. IL-10-592 A/C polymorphisms is associated with EBV-HLH in Chinese children. Hematology. 2016,21(2):95-98.
  4. Gu H, Xie Z, Li T, Zhang S, Lai C, Zhu P, Wang K, Han L, Duan Y, Zhao Z, Yang X, Xing L, Zhang P, Wang Z, Li R, Yu JJ, Wang X, Yang P.Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Sci Rep. 2016 Jan 27;6:19840. doi: 10.1038/srep19840.
  5. Wang Y, Li Y, Lu R, Zhao Y, Xie Z, Shen J, Tan W. Phylogenetic evidence for intratypic recombinant events in a novel human adenovirus C that causes severe acute respiratory infection in children.Sci Rep. 2016 Mar 10;6:23014. doi: 10.1038/srep23014.
  6. Xiang Z, Xie Z,Liu L, Ren L, Xiao Y, Paranhos-Baccalà G, Wang J. Genetic divergence of enterovirus D68 in China and the United States. Sci Rep. 2016 Jun 9;6:27800. doi: 10.1038/srep27800.
  7. Liu C, Xiao Y, Zhang J, Ren L, Li J, Xie Z, Xu B, Yang Y, Qian S, Wang J, Shen K. Adenovirus infection in children with acute lower respiratory tract infections in Beijing, China, 2007 to 2012. BMC Infect Dis. 2015, 15(1):408.
  8. Zhou C, Xie Z, Gao L, Liu C, Ai J, Zhang L, Shen K. Profiling of EBV-Encoded microRNAs in EBV-Associated Hemophagocytic Lymphohistiocytosis. Tohoku J Exp Med. 2015, 237(2):117-26.
  9. Yamin Li,  Weimin Zhou,  Yanjie Zhao,  Yanqun Wang,  Zhengde Xie,Yongliang Lou, Wenjie Tan. Molecular Typing and Epidemiology Profiles of Human Adenovirus Infection among Paediatric Patients with Severe Acute Respiratory Infection in China. PLoS ONE.2015, 10(4): e0123234.
  10. Xiang Z, Tsatsral S, Liu C, Li L, Ren L, Xiao Y, Xie Z, Zhou H, Vernet G, Nymadawa P, Shen K, Wang J. Respiratory infection with enterovirus genotype C117, China and Mongolia. Emerg Infect Dis. 2014, 20(6):1075-7.
  11. Weifeng Lu, Junhong Ai, Yali Liu, Chunyan Liu, Zhengde Xie＊. Characteristics of viral IL-10gene in Epstein–Barr virus infection in children in China. Future Virol.2014,9(10): 891-897.
  12. Liwei Gao, Zhengde Xie＊, Kunling Shen＊. Epstein-Barr Virus Associated Infectious Diseases in Children. J. Biomed. Sci. 2014, 6(4), 217-228; doi: 10.5099/aj140400217
  13. Chen Zhang, Na Zhu, Zhengde Xie#, Roujian Lu, Bin He, Chunyan Liu, Xuejun Ma, Wenjie Tan. Viral Etiology and Clinical Profiles of Children with Severe Acute Respiratory Infections in China. PLoS ONE, 2013, 8(8): e72606.
  14. Lu G, Li J, Xie Z#, Liu C, Guo L, Vernet G, Shen K, Wang J. Human metapneumovirus associated with community-acquired pneumonia in children in Beijing, China.J Med Virol. 2013, 85(1):138-43.
  15. Xiang Z, Xie Z, Wang Z, Ren L, Xiao Y, Li L, Vernet G, Paranhos-Baccalà G, Shen K, Wang J. Human enterovirus genotype C104, China [letter]. Emerg Infect Dis. 2013, 19(4): 689–691.
  16. LlU Chunyan, XlAO Yan, XlE Zhengde, REN Lili, HU Yinghui, YAO Yuan, YANG Yan, QIAN Suyun, ZHAO Chengsong, SHEN Kunling．Viral etiology of acute respiratory tract infection among pediatric inpatients and outpatients from 2010 to 2012 in Beijing， Chin J Pediatr. 2013, 51(4): 255-259.
  17. Naiying Mao, Yixin Ji, Zhengde Xie#, Huanhuan Wang, Huiling Wang, Junjing An,Xinxin Zhang, Yan Zhang, Zhen Zhu, Aili Cui, Songtao Xu, Kunling Shen, Chunyan Liu,Weizhong Yang, Wenbo Xu. Human Parainfluenza Virus-Associated Respiratory Tract Infection among Children and Genetic Analysis of HPIV-3 Strains in Beijing, China. PLoS ONE. 2012, 7(8): e43893.
  18. Ai J,Xie Z＊, Liu C, Huang Z, Xu J. Analysis of EBNA-1 and LMP-1 variants in diseases associated with EBV infection in Chinese children.Virol J. 2012, 11;9:13.
  19. Zhizhuo H, Junmei X, Yuelin S, Qiang Q, Chunyan L,Zhengde X＊, Kunling S＊. Screening the PRF1, UNC13D, STX11, SH2D1A, XIAP, and ITK gene mutations in Chinese children with Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis. Pediatr Blood Cancer. 2012;58(3):410-4.
  20. Qiang Q, Zhengde X, Shuang Y, Kunling S. Prevalence of Coinfection in Children with Epstein-Barr Virus-associated Hemophagocytic Lymphohistiocytosis.J Pediatr Hematol Oncol. 2012, 34(2):e45-e48.
  21. Qiang Q, Zhengde X, Chunyan L, Zhizhuo H, Junmei X, Junhong A, Zheng C, Henter JI, Kunling S. Killer cell immunoglobulin-like receptor gene polymorphisms predispose susceptibility to EBV associated hemophagocytic lymphohistiocytosis in Chinese children. Microbiol Immunol. 2012, 56: 378-384.
  22. XIE Zheng-de, XIAO Yan, LIU Chun-yan, HU Ying-hui, YAO Yuan, YANG Yan, QIAN Su-yun, GENG Rong, WANG Jian-wei, SHEN Kun-ling. Three years surveillance of viral etiology of acute lower respiratory tract infection in children from 2007 to 2010. Chin J Pediatr. 2011, 49(10): 745-749.
  23. Guo L, Gonzalez R, Xie Z,Zhou H, Liu C, Wu C, Paranhos-Baccalà G, Vernet G, Shen K, Jin Q, Wang J. Bocavirus in children with respiratory tract infections.   Emerg Infect Dis. 2011, 17(9):1775-7.
  24. Lili Ren, Richard Gonzalez,Zhengde Xie#, Zhaohui Xiong, Chunyan Liu, Zichun Xiang, Yan Xiao, Yongjun Li, Hongli Zhou, Jianguo Li, Qingqing Yang, Jing Zhang, Lan Chen, Wei Wang, Guy Vernet, Gláucia Paranhos-Baccalà, Kunling Shena, Jianwei Wang.Human parainfluenza virus type 4 infection in Chinese children with lower respiratory tract infections: A comparison study. J Clin Virol, 2011, 51(3): 209– 212.
  25. Li-Wei Gao, Zheng-De Xie, Ya-Yi Liu, Yan Wang, Kun-Ling Shen. Epidemiologic and clinical characteristics of infectious mononucleosis associated with Epstein-Barr virus infection in children in Beijing, China. World J Pediatr, 2011, 7(1): 45-49.
  26. Zichun Xiang, Richard Gonzalez, Zhengde Xie#, Yan Xiao, Jun Liu, Lan Chen, Chunyan Liu, Jing Zhang, Lili Ren, Guy Vernet, Gláucia Paranhos-Baccalà, Kunling Shen,, Qi Jin, Jianwei Wang. Human rhinovirus C infections mirror those of human rhinovirus A in children with community-acquired pneumonia.J Clin Virol, 2010; 49: 94–99.
  27. Lili Ren, Richard Gonzalez, Zhengde Xie, Yan Xiao, Yongjun Li, Chunyan Liu, Lan Chen, Qingqing Yang, Guy Vernet, Gláucia Paranhos-Baccalà, Qi Jin, Kunling Shen,and Jianwei Wang. Saffold Cardioviruses of 3 Lineages in Children with Respiratory Tract Infections, Beijing, China. Emerg Infect Dis , 2010; 16(7): 1158-1161.
  28. JIN Ying-kang, XIE Zheng-de, YANG Shuang, LU Gen, SHEN Kun-ling. Epstein-Barr virus-associated hemophagocytic lymphohistiocytosis: a retrospective study of 78 pediatric cases in mainland of China.Chin Med J. 2010;123(11) :1426-1430.
  29. Jin Y, Xie Z, Lu G, Yang S, Shen K. Characterization of variants in the promoter of BZLF1 gene of EBV in nonmalignant EBV-associated diseases in Chinese children. Virol J. 2010 May 10; 7:92.
  30. LU Gen, XIE Zheng-de＊, ZHAO Shun-ying, YE Ling-jun, WU Run-hui, LIU Chun-yan, YANG Shuang, JIN Ying-kang and SHEN Kun-ling＊. Clinical analysis and follow-up study of chronic active Epstein-Barr virus infection in 53 pediatric cases.Chin Med J, 2009; 122(3):262-266.
  31. LU Gen, XIE Zheng-de, SHEN Kun-ling, YE Ling-jun, WU Run-hui, LIU Chun-yan, JIN Ying-kang, YANG Shuang.Mutations in the perforin gene in children with hemophagocytic lymphohistiocytosis. Chin Med J, 2009;122(23) :2851-2855.
  32. WANG Yan, Yan Hui-min, ZHANG Hui, YAO Yuan, HU Yan, YAN Jing, XIE Zheng-de.＊. Significance of detection of Human Cytomegalovirus in 119 Infantile Cholestasis Syndrome. J Appl Clin Pediatr, 2009; 24(7): 511-512.）
  33. Zichun Xiang, Richard Gonzalez, Zhengde Xie,  Yan Xiao, Lan Chen, Yongjun Li, Chunyan Liu, Yinghui Hu, Yuan Yao, Suyun Qian,Rong Geng, Guy Vernet, Gláucia Paranhos-Baccalà, Kunling Shen, Qi Jin, and Jianwei Wang. Human Rhinovirus Group C Infection in Children with Lower Respiratory Tract Infection. Emerg Infect Dis, 2008; 14(10): 1665-1667.
  34. Lili Ren, Richard Gonzalez, Zhengde Xie,Jing Zhang, Chunyan Liu, Jianguo Li, Yongjun Li ,ZhongWangd, Xiaohui Kong, Yuan Yao, Yinghui Hu, Suyun Qian, Rong Geng, Yan Yang, Guy Vernet, Gláucia Paranhos-Baccalàb, Qi Jin, Kunling Shen, JianweiWang. WU and KI polyomavirus present in the respiratory tract of children, but not in immunocompetent adults. J Clin Virol, 2008; 43: 330-333.
  35. ZHANG Li-li, TANG Liu-ying, XIE Zheng-de, TAN Xiao-juan, LI Chong-shan, CUI Ai-li, JI Yi-xin, XU Song-tao, MAO Nai-ying, XU Wen-bo and SHEN Kun-ling. Human bocavirus in children suffering from acute lower respiratory tract infection in Beijing Children’s Hospital.Chin Med J, 2008; 121(17):1607-1610.
  36. XIE Zheng-de, ZHOU Chun-ju, WANG Lin, SHEN Kun-ling. Detection of C-terminal 30 bp-deletion mutation of latent membrane protein 1 of EBV in childhood lymphoma. Chin J Exp Clin Virol, 2008; 22(6): 464-467).