Executive Editor-in-Chief, Global Journal of Animal Sciences and Medicine

Ding Xiang Liu, PhD 
Professor 
South China Agriculture University Integrative Microbiology Research Centre Guangzhou, China 
Professor 
School of Biological Sciences 
Nanyang Technological University 
Singapore

Education

Ph.D. (1991) – Molecular Biology, University of Cambridge, UK.

M.Sc. (1986) – Medical Microbiology, Sichuan University (formerly West China University of Medical Sciences), Chengdu, Sichuan, China.

Diploma (1981) – Medical Laboratory Technology, Huangshi Institute of Technology (formerly Huangshi Health School), Huangshi, Hubei, China.

Selected publication

  1. K. Pervushin, E. Tan, K. Parthasarathy, X. Lin, F. L. Jiang, D. Yu, A. Vararatannavech, G. S. Wan, T. W. Soong, D. X. Liuand J. Torres*.  (2009).  Structure and inhibition of the SARS coronavirus envelope protein ion channel.  PLoS Pathogens5(7):e1000511.
  2. Yamada, and D. X. Liu*.(2009).  Proteolytic activation of the spike protein at a novel RRRR/S motif is implicated in furin-dependent entry, syncytium formation and infectivity of coronavirus infectious bronchitis virus in cultured cells.  Journal of Virology83, 8744-8758.
  3. Wang Y. Liao, P. L. Yap, K. J. Png, J. P. Tam, and D.X. Liu*.  (2009).  Inhibition of protein kinase R activation and up-regulation of GADD34 expression play a synergistic role in facilitating coronavirus replication by maintaining de novo protein synthesis in virus-infected cells.  Journal of Virology83, 12462-12472.
  4. G. Fang, H. Y. Shen, J. B. Wang, F. P. L. Tay, and D. X. Liu*.  (2010).  Functional and genetic studies of the substrate specificity of coronavirus infectious bronchitis virus 3C-like proteinase.  Journal of Virology84,7325-7336.
  5. H. Xu, S. Khadijah, S. G. Fang, L. Wang, F. P. L. Tay and D. X. Liu*. (2010). The cellular RNA helicase DDX1 interacts with coronavirus nonstructural protein 14 and enhances viral replication.  Journal of Virology84,8571-8583.
  6. M. A. Nasirudeen, H. H. Wong, P. L. Thien, S. Xu, K-P. Lam and D. X. Liu*.  (2011).  RIG-I, MDA5 and TLR3 synergistically play an important role in restriction of dengue virus infection.  PLoS Neglected Tropical Diseases5, e926.
  7. Liao, X. Wang, M. Huang, J. P. Tam and D. X. Liu*.(2011).Regulation of the p38 mitogen-activated protein kinase and dual-specificity phosphatase 1 feedback loop modulates the induction of interleukin 6 and 8 in cells infected with coronavirus infectious bronchitis virus. Virology 420, 106-116.
  8. H. Xu, M. Huang, S. G. Fang and D. X. Liu*. (2011). Coronavirus Infection Induces DNA replication stress partly through interaction of its nonstructural protein 13 with the p125 subunit of DNA polymerase delta. Journal of Biological Chemistry286,39546-59.
  9. Y. W. Tan, W. Hong and D. X. Liu*. (2012).Binding of the 5’-untranslated region of coronavirus RNA to zinc finger CCHC-type and RNA binding motif 1 enhances viral replication and transcription. Nucleic Acids Research40 (11):5065-5077.
  10. K-G Lee, S. Xu, Z-H Kang, J. Huo, M. Huang, X. Liu,O. Takeuchi, S. Akira, and K-P. Lam*. (2012). Bruton’s tyrosine kinase phosphorylates Toll-like receptor 3 to initiate anti-viral response. Proceedings of the National Academy of Sciences of the United States of America 109, 5791-5796.
  11. Yanxin Zhong, Yong Wah Tan and X. Liu*.(2012). Recent progress in studies of arterivirus- and coronavirus-host interactions (review). Viruses4, 980-1010.
  12. Felicia P. L. Tay, Mei Huang, Li Wang, Yoshiyuki Yamada and X. Liu*. (2012). Characterization of cellular furin content as a potential factor determining the susceptibility of cultured human and animal cells to coronavirus infectious bronchitis virus infection. Virology433, 421-430.
  13. Hui-Chen Guo, Shi-Qi Sun, Ye Jin, Shun-Li Yang, Shuang-Hui Yin, Jun-Wu Ma, Zai-Xin Liu, Jian-Hong Guo, Jian-Xiong Luo, Hong Yin, Xiang-Tao Liu and X. Liu*.(2013). Foot-and-mouth disease virus-like particles produced by a SUMO fusion protein system in Escherichia coli induce potent protective immune responses in guinea pigs, swine and cattle. Veterinary Research44, 48.
  14. Hui-Chen Guo, Shi-Qi Sun, De-Hui Sun, Yan-Quan Wei, Jin Xu, Mei Huang, Xiang-Tao Liu, Zai-Xin Liu, Jian-Xiong Luo, Hong Yin and X. Liu*.(2013). Viroporin activity and membrane topology of classic swine fever virus p7 protein. The International Journal of Biochemistry & Cell Biology45, 1186-1194.
  15. Ying Liao, To Sing Fung, Mei Huang, Shou Guo Fang, Yanxin Zhong and X. Liu*. (2013). Up-regulation of CHOP/GADD153 during Coronavirus Infectious Bronchitis Virus Infection Modulates Apoptosis by Restricting Activation of the Extracellular Signal-Regulated Kinase Pathway. Journal of Virology87,8124-8134.
  16. Shouguo Fang, Linghui Xu, Mei Huang, Frank Qisheng Li and X. Liu*. (2013). Identification of two ATR-dependent phosphorylation sites on coronavirus nucleocapsid protein with nonessential functions in viral replication and infectivity in cultured cells. Virology444,225-232.
  17. Yan-Quan Wei, Hui-Chen Guo, Hu Dong, Hai-Ming Wang, Jin Xu, De-Hui Sun, Shou-Guo Fang, Xue-Peng Cai, X. Liu*,and Shi-Qi Sun*. (2014). Development and characterization of a recombinant infectious bronchitis virus expressing the ectodomain region of S1 gene of H120 strain. Applied Microbiology and Biotechnology98(4):1727-35.
  18. To Sing Fung and X. Liu*. (2014). Coronavirus infection, ER stress, Apoptosis and Innate Immunity (review). Frontiers in MicrobiologyVolume:5, Article Number: 296.   Published: JUN 17 2014.
  19. X. Liu*, To Sing Fung, Kelvin Kian Long Chong, Aditi Shukla and Rolf Hilgenfeld. (2014). Accessory proteins of SARS-CoV and other coronaviruses (review). Antiviral Research109:97-109.
  20. To Sing Fung, Ying Liao and X. Liu*. (2014). The ER stress sensor IRE1α protects cells from apoptosis induced by coronavirus infectious bronchitis virus. Journal of Virology88(21):12752-12764.
  21. To Sing Fung, Jaume Torres and X. Liu*.(2015). The emerging roles of viroporins in ER stress response and autophagy induction during virus infection (review). Viruses7, 2834-2857.
  22. Hui Hui Wong, Pankaj Kumar, Felicia Tay, Dimitri Moreau, X. Liu*, and Frederic Bard*. (2015). Genome-wide screen reveals VCP requirement for coronavirus exit from endosomes. Journal of Virology89,11116-11128.
  23. Phuong Quoc Thuc Nguyen, Justin Seng Geap Ooi, Ngan Thi Kim Nguyen, Shujing Wang, Mei Huang, X. Liuand James P Tam*. (2015). Antiviral Cystine Knot α-Amylase Inhibitors from Alstonia scholaris. Journal of Biological Chemistry 2015 Nov 6. pii: jbc.M115.654855. [Epub ahead of print].
  24. Shi-Chong Han, Hui-Chen Guo, Shi-Qi Sun*, Ye Jin, Yan-Quan Wei, Xia Feng, Xue-Ping Yao, Sui-Zhong Cao,  X. Liu, Xiang-Tao Liu. (2016). Productive entry of foot-and-mouth disease virus via macropinocytosis independent of phosphatidylinositol 3-kinase. Scientific Reports6:19294. doi: 10.1038/srep19294.
  25. Fung TS, Liao Y, X. Liu*. (2016). Regulation of Stress Responses and Translational Control by Coronavirus. Viruses4;8(7). pii: E184. doi: 10.3390/v8070184.
  26. To J, Surya W, Fung TS, Li Y, Verdià-Bàguena C, Queralt-Martin M, Aguilella VM, X. Liu*,Torres J*. (2017). Channel inactivating mutations and their revertant mutants in the envelope protein of the infectious bronchitis virus. J Virol. 2017 Feb 14;91(5). pii: e02158-16.