Research Article
Expression of PLG in Kidney Renal Clear Cell Carcinoma and its Significance
Chao-Qun Xing1,*, Jiang-Rong Huang 1,*,✉
1 Department of Traditional Chinese Medicine, Health Science Center, Yangtze University, Jingzhou 434023, China. These authors contributed equally. ✉ Correspondence Jiang-Rong Huang, Department of Traditional Chinese Medicine, Health Science Center, Yangtze University, Jingzhou, Hubei Province, China, 434023, China. Phone: +86-13607216868.; Email: [email protected]. Received: July 31, 2020. Accepted: October 14, 2020. Published online: December 30, 2020. Cite this paper: Chao-Qun Xing, Jiang-Rong Huang (2020) Expression of PLG in Kidney Renal Clear Cell Carcinoma and its Significance. Global Journal of Life Sciences, 1(2): 49-62. https://naturescholars.com/gjls.010107. https://doi.org/10.46633/gjls.010107. Copyright© 2020 by Scholars Publishing, LLC.
Abstract
We aimed to identify if Plasminogen (PLG) could be used as a new diagnostic and therapeutic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) patient. Expression of PGL in KIRC was analyzed by using GEPIA (Gene Expression Profiling Interactive Analysis) and UALCAN databases. GEPIA and CBioPortal tools were applied to determine patients’ survival and PLG mutations, respectively. PPI (Protein-Protein Interaction) networks were further built by STRING (Search Tool for the Retrieval of Interacting Genes) Web portals. The data demonstrated that the expression of PLG in KIRC was significantly enhanced when compared to normal kidney tissues (P < 0.001). A lower PLG expression resulted in a remarkably shorter overall survival. Moreover, the expression of PLG in KIRC was related to KIRC patients’ stages, race and grade. PPI networks and GO enrichment analysis suggested that PLG might be associated with negative regulation of cellular protein metabolic process and complement and coagulation cascades signaling pathway etc. Finally, five specific gene mutations L469P, S292C, X317_splice, Y530C and N809S of PLG occurred in KIRC and these unique mutations were not seen in any other tumor tissues. Taken together, our novel findings suggest that PLG is implicated in the poor prognosis of KIRC.
Key word: Plasminogen (PLG), Kidney Renal Clear Cell Carcinoma (KIRC), TCGA, Biomarker, Cancer Therapy.