Executive Editor-in-Chief, GJLS

Changshan Wang, MD
Professor
School of Life Sciences
Inner Mongolia University
Hohhot, China
Special Foreign Investigator
Institute of Medical Research
National Chiba University
Chiba, Japan

Member, Japan Hematology Association
Member, United States of America Hematology Association
Member, International Stem Cell Association

Education
Post-Doctoral Fellow, National Chiba University, Japan
MD, National Chiba University, Japan

Selected publication

  1. Masafumi Seki1 , Shunsuke Kimura , Tomoya Isobe1, Kenichi Yoshida, Hiroo Ueno, Yaeko Nakajima-Takagi, Changshan Wang, Lin Lin, Ayana Kon, Hiromichi Suzuki, Yusuke Shiozawa, Keisuke Kataoka, Yoichi Fujii, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Teppei Shimamura, Kyoko Masuda, Hiroshi Kawamoto, Kentaro Ohki, Motohiro Kato, Yuki Arakawa, Katsuyoshi Koh, Ryoji Hanada, Hiroshi Moritake, Masaharu Akiyama, Ryoji Kobayashi, Takao Deguchi, Yoshiko Hashii, Toshihiko Imamura, Atsushi Sato, Nobutaka Kiyokawa, Akira Oka, Yasuhide Hayashi, Masatoshi Takagi, Atsushi Manabe, Akira Ohara, Keizo Horibe, Masashi Sanada, Atsushi Iwama, Hiroyuki Mano, Satoru Miyano, Seishi Ogawa, & Junko Takita1. Recurrent PU.1 fusions in high-risk pediatric T cell acute lymphoblastic leukemia. Nature genetics（IF 31.616）
  2. Ola Rizq, Naoya Mimura, Motohiko Oshima, Atsunori Saraya, Shuhei Koide, Yuko Kato, Kazumasa Aoyama, Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, Anqi Ma, Jian Jin, Tohru Iseki, Chiaki Nakaseko, and Atsushi Iwama. Dual inhibition of EZH2 and EZH1 sensitizes PRC2-dependent tumors to proteasome inhibition. Clinical cancer research.（IF 8.738 in press）
  3. Nagisa Hasegawa, Motohiko Oshima, Goro Sashida, Hirotaka Matsui, Shuhei Koide, Atsunori Saraya, Changshan Wang, Tomoya Muto, Kiyoko Takane, Atsushi Kaneda, Kazuya Shimoda, Chiaki Nakaseko, Koutaro Yokote, and Atsushi Iwama. Impact of combinatorial dysfunctions of Tet2 and Ezh2 on the epigenome in the pathogenesis of myelodysplastic syndrome. Leukemia 2016 （IF12.104）
  4. Goro Sashida#, Changshan Wang#, Takahisa Tomioka, Motohiko Oshima, Kazumasa Aoyama, Akinori Kanai, Makiko Mochizuki-Kashio, Hironori Harada, Kazuya Shimoda, and Atsushi Iwama. The loss of Ezh2 drives the pathogenesis of myelofibrosis and sensitizes tumor-initiating cells to bromodomain inhibition. Journal of Experimental Medicine 2016; 213(8): 1459-77. # equal contribution（IF12.515）
  5. Motohiko Oshima, Nagisa Hasegawa, Makiko Mochizuki-Kashio, Tomoya Muto, Satoru Miyagi, Shuhei Koide, Shogo Yabata, George Russel Wendt, Atsunori Saraya, Changshan Wang, Kazuya Shimoda, Yutaka Suzuki, Atsushi Iwama. Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells. Experimental Hematology.2016 Apr;44(4):282-296.e3.（IF2.475）
  6. Makiko Mochizuki-Kashio, Kazumasa Aoyama, Goro Sashida, Motohiko Oshima, Takahisa Tomioka, Tomoya Muto, Changshan Wang, and Atsushi Iwama. Ezh2 loss in hematopoietic stem cells predisposes mice to develop heterogeneous malignanciesin an Ezh1-depenedent manner. Blood 2015; 126(10): 1172-83.（IF 11.841）
  7. Changshan Wang*, Motohiko Oshima, Goro Sashida, Takahisa Tomioka, Nagisa Hasegawa, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Yoichiro Kusunoki, Seishi Kyoizumi, Kazue Imai, Kei Nakachi, Atsushi Iwama. Non-Lethal Ionizing Radiation Promotes Aging-Like Phenotypic Changes of Human Hematopoietic Stem and Progenitor Cells in Humanized Mice. PLoS One. 2015 Jul 10;10 (7):e0132041（IF 3.234）
  8. YutaMishima#, Changshan Wang #, Satoru Miyagi #, Atsunori Saraya#, Hiroyuki Hosokawa, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Shuhei Koide, Masamitsu Negishi, Goro Sashida, Taku Naito, Tomoyuki Ishikura, Atsushi Onodera, Toshinori Nakayama, Daniel G. Tenen, Naoto Yamaguchi, Haruhiko Koseki, Ichiro Taniuchi & Atsushi Iwama. Histone acetylation mediated by Brd1 is crucial for Cd8 gene activation during early thymocyte development. Nature communications. 2014; 5: 5872. # equal contribution （IF 11.47）
  9. Changshan Wang, Goro Sashida, Atsunori Saraya, Reiko Ishiga, Shuhei Koide, Motohiko Oshima, Kyoichi Isono, Haruhiko Koseki, and Atsushi Iwama. Depletion of Sf3b1 impairs proliferative capacity of hematopoietic stem cells but is not sufficient to induce myelodysplasia. Blood. 2014;123(21): 3336-43.（IF 11.841）
  10. Goro Sashida, Hironori Harada, Hirotaka Matsui, Motohiko Oshima, MakikoYui, Yuka Harada, Satomi Tanaka, Makiko Mochizuki-Kashio, Changshan Wang, Atsunori Saraya, Tomoya Muto,Yoshihiro Hayashi, Kotaro Suzuki, Hiroshi Nakajima, Toshiya Inaba, Haruhiko Koseki, Gang Huang, Toshio Kitamura & Atsushi Iwama. Ezh2 loss promotes RUNX1 mutant-induced myelodysplastic syndrome in cellintrinsic and extrinsic manners. Nature communications.5:4177. doi: 10.1038/ncomms5177. (IF 11.470)
  11. Satoru Miyagi, Shuhei Koide, GeorgeR. Wendt, Motohiko Oshima, Takaaki Konuma, Satoshi Yamazaki, Makiko Mochizuki-Kashio,Yaeko Nakajima-Takagi, Changshan Wang, Tetsuhiro Chiba, IssayKita bayashi, Hiromitsu Nakauchi, and Atsushi Iwama. The Tif1 -Hp1 system maintains transcriptional integrity of hematopoietic stem cells, Stem Cell Reports.2014 Jan 23;2(2):145-52.（IF 7.023）
  12. Yuki Hayashi, Takao Kuroda, Hiroyuki Kishimoto, Changshan Wang, Atsushi Iwama, Keiji Kimura. Downregulation of rRNA transcription triggers cell differentiation. PLoS ONE 9:e98586, 2014. （IF 3.234）
  13. Changshan Wang, Shunsuke Nakamura, Motohiko Oshima, Makiko Mochizuki-Kashio, Yaeko Nakajima-Takagi, Mitsujiro Osawa ,Yoichiro Kusunoki , Seishi Kyoizumi , Kazue Imai , Kei Nakachi and Atsushi Iwama. Compromised hematopoiesis and increased DNA damage following non-lethal ionizing radiation of a human hematopoietic system reconstituted in immunodeficient mice. International Journal of Radiation Biology 89, 132-137, 2013, Feb. （IF 1.687）
  14. Taito Nishino, Changshan Wang, Makiko Mochizuki-Kashio, Mitsujiro Osawa, Hiromitsu Nakauchi, Atsushi Iwama. Ex vivo expansion of human hematopoietic stem cells by Garcinol, a potent inhibitor of histone acetyltransferase.PLoS ONE 6: e24298, 2011（IF 3.234）
  15. Yusuke Takeda, Chiaki Nakaseko, Hiroaki Tanaka, Masahiro Takeuchi, Makiko Yui, Atsunori Saraya, Satoru Miyagi, Changshan Wang, Satomi Tanaka, Chikako Ohwada, Emiko Sakaida, Naoto Yamaguchi, KoutaroYokote, Lothar Hennighausen and Atsushi Iwama. Direct activation of STAT5 by ETV6-Lyn fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis. British Journal of Hematology. 153, 589-598, 2011.（IF 4.711）
  16. Shunsuke Suzuki, Ryuichi Ono, Takanori Narita, Andrew J. Pask, Geoffrey Shaw, Changshan Wang, Takashi Kohda, Amber E. Alsop, Jennifer A. Marshall Graves,YujiKohara, Fumitoshi Ishino, Marilyn B. Renfree, Tomoko Kaneko-Ishino. Retrotransposon Silencing by DNA Methylation Can Drive Mammalian Genomic Imprinting. PLOS GENETICS. ( 2007 ) Apr 13;3 (4).（IF 7.528）