Research Article

Tranexamic Acid for Reducing Bleeding in Transurethral Resection of The Prostate: A Meta-Analysis and Systematic Review

Xin-Zhi Zhou and Zhi-Ping Yu*

Operating Room of Jingzhou Central Hospital, Jingzhou, 434000, Hubei, China.

*, Corresponding author.
Zhi-Ping Yu, BSN, Operating Room of Jingzhou Central Hospital, Jingzhou, 434000, Hubei, China. Phone number：86+15377180870. Email: [email protected].
Received: November 28, 2023; Accepted: March 1, 2024; Published online: June 8, 2024.
Cite this paper: Xin-Zhi Zhou and Zhi-Ping Yu. (2024) Tranexamic Acid for Reducing Bleeding in Transurethral Resection of The Prostate: A Meta-Analysis and Systematic Review. Global Journal of Medicine, 5(1):21-30. http://naturescholars.com/gjm.050103. https://doi.org/10.46633/gjm.050103.
Copyright© 2024 by Scholars Publishing, LLC.

Abstract

Objective: The efficacy of tranexamic acid (TXA) for reducing bleeding during transurethral resection of the prostate is still inconclusive. To understand its efficacy and safety in transurethral resection of the prostate literature results were meta-analyzed and systematically reviewed. Methods: We searched PubMed, Web of Science, The Cochrane Library, and Embase database, and finally retrieved 9 articles, and screened titles and abstracts according to our inclusion and exclusion criteria. Only randomized controlled trials (RCTs) were included in the analysis, and the trials should include at least 2 subgroups: the TXA group and the control group. Results: Nine RCTs were eligible for this meta-analysis and systematic review. The results of the meta-analysis showed that, compared with the control group, the TXA group had higher hemoglobin 24 hours after surgery [SMD=0.55, 95%CI (0.18, 0.92), P=0.003], and less intraoperative blood loss [SMD=- 2.20, 95%CI (-3.45, -0.96), P=0.0005]. Blood transfusion rate was lower [SMD=0.53, 95%CI (0.30, 0.96), P=0.04], while other aspects such as hemoglobin loss at 24h after operation [SMD=-0.08, 95%CI (-0.29, 0.13), P=0.46], operation time [SMD=-0.28, 95%CI (-0.83, 0.27), P=0.31], hospital stay [SMD=0.07, 95%CI (-0.11, 0.24), P=0.45] had no significant difference. Conclusion: Tranexamic acid can reduce blood loss and blood transfusion rate during transurethral resection of the prostate, and maintain a higher hemoglobin level 24 hours after surgery, without increasing the risk of thromboembolism and other complications. High clinical application value was obtained for clinical recommendation.

Keywords

Tranexamic Acid; Transurethral Resection; Prostate; Temoglobin; Bleeding.