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Research Article

Postoperative Effect of Short-Term Treatment with Fluorometholone Combined with Pranoprofen on LASEK

Fan Peng^*, Xiangqiong Liu

Department of Laser Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, 434000, China.

*, Correspondence

Fan Peng, Department of Laser Ophthalmology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, 434000, China. Telephone number: 18163138979. E-mail: [email protected].

Received: July 21, 2023; Accepted: May 1, 2024; Published online: September 5, 2024.

Cite this paper: Fan Peng, Xiangqiong Liu. (2024) Postoperative effect of short-term treatment with fluorometholone combined with pranoprofen on LASEK. Global Journal of Medicine, 5(2):22-37. http://naturescholars.com/gjm.050203. https://doi.org/10.46633/gjm.050203.

Abstract

Objective: To compare the effect of fluoromethalone combined with pranoprofen eye drops in short and long term after excimer laser subepithelial keratomileusis (LASEK) and to probe its impact on the postoperative effect. Method：We selected myopia patients who underwent laser subepithelial keratomileusis (LASEK) in the Department of Laser Ophthalmology, the First Affiliated Hospital of Yangtze University. According to the length of using fluorometholone eye drops after LASEK divided into control and experimental group, the patients who were used for four months ( long course of treatment) from March 2008 to March 2010 as the control group, and those were used for one month (short course of treatment) from October 2012 to December 2012 were set as the experimental group, thus，to compare the differences of uncorrected visual acuity, diopter, intraocular pressure, slit-lamp examination and the occurrence of corneal haze with different medication time points. Result: There was no statistically significant difference in the postoperative uncorrected visual acuity (UCVA) and postoperative refractive power between the two groups at each time points within 1 year and 5 years. The difference of intraocular pressure between the two groups at 2 months, 3 months, and 4 months were statistically significant compared with expected intraocular pressure of postoperative. Comparing the incidence of increased intraocular pressure> 3 mmHg, the control groups and experimental groups’ incidences were 12% and 2.5%, respectively. The incidence of haze was 8% and 11.25%, respectively, the experimental group showed mild evidence higher than the control groups, but there is no statistically significant. Conclusions：The short-term treatment of fluorometholone combined with pranoprofen eye drops and the long-term treatment group was equally effective in maintaining postoperative uncorrected visual acuity and postoperative diopter stability. But, the short-term group was better at preventing elevated intraocular pressure, and the incidence was lower than the long-term group. There was no difference between the two groups in preventing and reducing the incidence of haze. The postoperative safety, efficacy and stability between the two groups makes no difference, which is worthy of popularization in clinical practice.

Key words: myopia, LASEK, NSAIDs, glucocorticoids, haze.