Research Article
Effect of Shenqi Jiangtang Granule and Metformin in the Treatment of Type 2 Diabetes Mellitus
Yuan-Yuan Xing1,2, Dan Liu3, Zu-Mei Gao1,✉
1The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, China; 2Health Science Centre, Yangtze University, Jingzhou, Hubei 434023, China; 3The Seventh Affiliated Hospital of Zhongshan University, Shenzhen, Guangdong 518000, China ✉ Correspondence Zu-Mei Gao, Department of Nursing, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, China. Email:[email protected]. Telephone number: 18972161212. Received: June 29, 2019; Accepted: August 24, 2019; Published online: September 7, 2019 Cite this paper: Yuan-Yuan Xing, Dan Liu, Zu-Mei Gao. (2020) Effect of Shenqi Jiangtang Granule and Metformin in the Treatment of Type 2 Diabetes Mellitus. Global Journal of Medicine, 1(1):2-9. https://naturescholars.com/gjm.010102. https://doi.org/10.46633/gjm.010102. Copyright © 2020 by Scholars Publishing, LLC
Abstract
Objective: To investigate the effects of Shenqi Jiangtang Granule combined with metformin on blood sugar, lipid, immune function, oxidative stress and therapeutic effect in patients with T2DM. Methods: 128 patients with T2DM who were treated in an AAA-class hospital in Jingzhou from September 2016 to April 2018 were randomly divided into control group and experimental group, 64 cases in each group by random number table method. The control group received routine symptomatic treatment, namely metformin, while the experimental group received Shenqi Jiangtang Granule on the basis of the control group. The changes of blood sugar, lipid, immune function and oxidative stress were compared between the two groups before and after treatment, and the therapeutic effect was observed. Results: After treatment, the levels of FPG, 2hPBG, HbA1c, TC, TG, CD8+ and MDA in the two groups were significantly lower than those before treatment, and the levels of CD4+, CD4+/CD8+, T-AOC and GSH-px in the two groups were significantly higher than those before treatment. After treatment, the levels of FPG, 2hPBG, HbA1c, TC, TG, CD8+ and MDA in the experimental group were significantly lower than those in the control group, while the levels of CD4+, CD4+/CD8+, T-AOC and GSH-px in the experimental group were significantly higher than those in the control group. The total clinical effective rate of the experimental group (92.19%) was significantly higher than that of the control group (73.44%). The differences of the above results were statistically significant (P < 0.05). There was no adverse reactions occurred during the treatment. Conclusion: Shenqi Jiangtang Granule combined with metformin can improve the levels of blood sugar and lipid, enhance immune function, reduce oxidative stress response and effectively improve the therapeutic effect of patients with T2DM, so it has clinical popularization significance.
Key words: Shenqi Jiangtang Granule, Metformin, T2DM, Immune Function, Oxidative Stress