Research Article
The association between miR-155 promoter polymorphism and risk of sepsis in a Chinese Han population
Ping-Fan Zhao1,*, Bo Xia2,*, Yan-Hua Lv1,*, Tian Zhao4, Ji-Yuan Yang1,✉
1Department of Oncology, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, China; 2Department of Pathology, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, China; 4The Intensive Care Unit, Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangd ong Medical University, Zhanjiang, Guangzhou , 524000, China *, These authors contributed equally. ✉ , Correspondence Ji-Yuan Yang, Department of Oncology, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, China. Email: [email protected] number: 15927960156. Received: June 2, 2019; Accepted: August 13, 2019; Published online: September 7, 2019. Cite this paper: Ping-Fan Zhao, Bo Xia, Yan-Hua Lv, Tian Zhao, Ji-Yuan Yang. (2020) The association between miR-155 promoter polymorphism and risk of sepsis in a Chinese Han population. Global Journal of Medicine, 1(1):10-21. https://naturescholars.com/gjm.010103. https://doi.org/10.46633/gjm.010103. Copyright © 2020 by Scholars Publishing, LLC.
Abstract
Background: miR-155 has been demonstrated play a critical role in the pathogenesis of sepsis. Little is known about the potential clinical relevance of genetic variants in the promoter of miR-155 and sepsis risk. Aims：This study aims to evaluate the association between miR-155 promoter rs767649 T>A polymorphism and the sepsis onset and development. Study Design: we carried out this hospital-based case-control study to investigate whether the genetic polymorphism of rs767649 was associated with the risk and progression of sepsis in a Chinese Han population. Methods: A total of 579 sepsis patients and 748 matched healthy controls of Chinese Han population were consecutively enrolled. Pyrosequencing and polymerase chain reaction-length polymorphism method was conducted to determine the genotype of the rs767649 site. Results: No significant association was observed between rs767649 T > A polymorphism and the sepsis susceptibility, but subgroup analysis revealed rs767649 SNP may be a risk factor for sepsis progression. Conclusion: Our data initially indicated that miR-155 promoter rs767649 T>A polymorphism may not be a genetic risk factor for sepsis occurrence but is associated with the development of sepsis in Chinese Han population. However, extensive studies are needed to gain more reliable and authentic results.
Key words: Sepsis; miR-155; Polymorphism; rs767649