Research Article

Effect of Sijunzi Decoction on Regulating Intestinal Flora and Enhancing Immune Function in Patients with Colorectal Cancer

Xiaoling Yin^1,*, Yu Cheng², Jieyu Zou³, QianYu³ , and Wei Jiang⁴

1. Department of Oncology, ChongQing Ninth People’s Hospital, ChongQing, 400600, China. 2. JiNan Medical University, GuangDong, 750004, China. 3. ChongQing Medical University, ChongQing, 400700, China. 4. Department of Traditional Chinese Medicine, ChongQing Ninth People’s Hospital, ChongQing, 400600, China.

*，Correspondence
Xiaoling Yin, Department of Oncology, ChongQing Ninth People's Hospital, 69 Jialing Village, Beibei District, ChongQing, 400700, China. Email: [email protected]. Telephone number: 13896087467.
Received: February 4, 2022; Accepted: June 4, 2022; Published: August 2, 2022.
Cite this paper: Xiaoling Yin, Yu Cheng, Jieyu Zou, QianYu, and Wei Jiang. (2022) Effect of Sijunzi Decoction on Regulating Intestinal Flora and Enhancing Immune Function in Patients with Colorectal Cancer. Global Journal of Microbiology, 3(1): 14-20. http://naturescholars.com/gjmic.030102. https://doi.org/10.46633/gjmic.030102
Copyright © 2022 by Scholars Publishing, LLC.

Abstract

To study the regulatory effect of Sijunzi Decoction on intestinal flora and immune function in patients with colorectal cancer. 100 patients with colorectal cancer were divided into two groups. The control group was received routine chemotherapy, and the experimental group was taking Sijunzi Decoction based on routine chemotherapy. 16S RNA amplicon sequencing was used to quantitatively detect the intestinal flora, and the immune function of the patients was detected by Flow cytometry analysis. The digestive tract reaction was significantly reduced by Sijunzi Decoction, and the abundance of intestinal Lactobacillus and  Bifidoacterium were increased, but the abundance of Enterobacteria and fusobacterium nucleatum were reduced. The proportion of CD4 + / CD8 + cells was increased as shown by Flow cytometry analysis. The species and abundance of intestinal flora were changed, and the immune function of patients with colorectal cancer were significantly improved by Sijunzi Decoction.

 Key words: Sijunzi Decoction; Colorectal Cancer; Intestinal Flora; Immune Function.