Research Article
Effect of Oral Administration of Chlorhexidine Gargle Combined with Toothbrushing on The Prevention of Ventilator-Associated Pneumonia: A Meta-Analysis of Randomized Controlled Trials
Pan-Pan Zheng1, Ling Zhang2✉, Rui Sun1, Xiao-Yan Peng2
1The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, China; 2Health Science Centre, Yangtze University, Jingzhou, Hubei 434023, China.
✉ Correspondence Ling Zhang, Department of Nursing, the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434023, China. Email: [email protected]. Telephone number: 18972161523. Received: July 9, 2019; Accepted: November 6, 2019; Published online: June 7, 2020. Cite this paper: Zheng, P.P., Zhang, L., Sun, R., and Peng, X.Y. (2020) Effect of oral administration of chlorhexidine gargle combined with toothbrushing on the prevention of ventilator-associated pneumonia: a meta-analysis of randomized controlled trials. Global Journal of Microbiology, 1(1): 2-10. https://naturescholars.com/gjmic.010102. https://doi.org/10.46633/gjmic.010102. Copyright© 2020 by Scholars Publishing, LLC.
Abstract
Objective: To evaluate the effect of oral administration of chlorhexidine gargle combined with toothbrushing scrubbing on the prevention of ventilator-associated pneumonia in mechanically ventilated patients. Methods: Randomized controlled clinical trials about the effect of chlorhexidine combined with toothbrushing on the incidence of ventilator-associated pneumonia (VAP) were retrieved from the databases including PubMed, Cochrane Library, Web of Science, CNKI, CMB, Wan Fang and VIP, et al. After data extraction and methodological quality evaluation, RevMan5.3 software was used for data analysis. Results: A total of 1370 patients were included in 6 studies, and the results of meta-analysis showed that the application of chlorhexidine gargling solution combined with toothbrushing can significantly reduce the incidence of VAP, shorten the time of mechanical ventilation, shorten the length of ICU stay and reduce the mortality of patients (all P<0.05).Conclusion: The oral nursing plan of chlorhexidine gargling combined with toothbrushing can significantly reduce the incidence of VAP, shorten the time of mechanical ventilation, shorten the length of ICU stay and reduce the mortality of patients. Due to the differences in specific implementation schemes, rigorous and high-quality research are still needed to confirm the application advantages of this scheme.
Key words: Oral nursing; Toothbrushing; Mechanical ventilation; Ventilator-associated pneumonia; Meta-analysis.