Xihe Zhang, Ph.D
Associate Professor
Lianjiang People’s Hospital
Guangdong Medical University
Guangdong, China

Selected publication
[1] Xi-He Zhang, Xiao-Dong Lian, Zheng-Xi Dai, Hong-Yi Zheng, Xin Chen, Yong-Tang Zheng. α3-Deletion Isoform of HLA-A11 Modulates Cytotoxicity of Natural Killer Cells: Correlations with HIV-1 Infection of Cells. J Immunol. 2017.199(6):2030-2042.
[2] Xihe Zhang, Jing Shi, Xusheng Qiu, Qingqing Chai, Dylan Frabutt, Richard Schwartz, and Yong-Hui Zheng. CD4 expression and Env conformation are critical for HIV-1 restriction by SERINC5. 2019 May 1; J Virol, pii: JVI.00544-19. doi: 10.1128/JVI.00544-19.
[3] Zhang XH, Dai ZX, Zhang GH, Han JB, Zheng YT. Molecular characterization, balancing selection, and genomic organization of the tree shrew (Tupaia belangeri) MHC class I gene. Gene. 2013; 522(2):147-55.
[4] Shi J, Xiong R, Zhou T, Su P, Zhang X, Qiu X, Li H, Li S, Yu C, Wang B, Ding C, Smithgall TE, Zheng YH. HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system. J Virol. 2018.doi: 10.1128/JVI.00196-18.
[5] Zhang X, Zhou T, Yang J, Lin Y, Shi J, Zhang X, Frabutt DA, Zeng X, Li S, Venta PJ, Zheng YH. Identification of SERINC5-001 as the Predominant Spliced Isoform for HIV-1 Restriction. J Virol. 2017; 28;91(10)
[6] Wang B, Wang Y, Frabutt DA, Zhang X, Yao X, Hu D, Zhang Z, Liu C, Zheng S, Xiang SH, Zheng YH. Mechanistic understanding of N-glycosylation in Ebola virus glycoprotein maturation and function. J Biol Chem. 2017; 7;292(14):5860-5870.
[7] Lian X D, Zhang X H, Dai Z X, et al. Characterization of classical major histocompatibility complex (MHC) class II genes in northern pig-tailed macaques (Macaca leonina). Infection, Genetics and Evolution, 2017, 56: 26-35.
[8] Lian X D, Zhang X H, Dai Z X, et al. Identification of the major histocompatibility complex class-II DM and DO alleles in a cohort of northern pig-tailed macaques (Macaca leonina). Immunogenetics, 2017: 1-7.
[9] Lian X D, Zhang X H, Dai Z X, et al. Cloning, sequencing, and polymorphism analysis of novel classical MHC class I alleles in northern pig-tailed macaques (Macaca leonina). Immunogenetics, 2016, 68(4): 261-274.
[10] Zhang GH, Han JB, Zhu L, Luo RH, Zhang XH, Chen X, Hu YJ, Fu LC, Zheng YT. Aikeqing decreases viral loads in SHIV89.6-infected Chinese rhesus macaques. Chin Med. 2016;11:31.
[11] Dai ZX, Zhang GH, Zhang XH, Zhu JW, Zheng YT. A splice variant of HLA-A with a deletion of exon 3 expressed as nonmature cell surface glycoproteins forms aheterodimeric structure with full-length HLA-A. Hum Immunol. 2014; 75(3):234-8.
[12] Dai ZX, Zhang GH, Zhang XH, Zheng YT. Identification and characterization of a novel splice variant of rhesus macaque MHC IA. Mol Immunol. 2013; 53(3): 206-13.
[13] Dai ZX, Zhang GH, Zhang XH, Xia HJ, Li SY, Zheng YT. The beta2-microglobulin-free heterodimerization of rhesus monkey MHC class I A with its normally spliced variant reduces the ubiquitin-dependent degradation of MHC class I A. J Immunol 2012; 188, 2285–2296.
BOOK
Zhang XH, Zheng YT. 2014. Basic Biology and Disease Models of Tree Shrew (Chapter 4). Yunnan Science Press Kunming. pp515-546.