Review
Application of Gut Microbiomes in The Diagnosis and Treatment of Cancer
Ling Shao1,#, Shen Qian2,#, Jianghong An1,#,*, Xiaohua Tan1,*
1Department of Oncology and Hematology, Third People’s Hospital of Shenzhen, The Second Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518000, China. 2Department of Respiratory and Critical Care Medicine, The First Medical Center, Chinese PLA General Hospital, Beijing 100000, China.
#, These authors contributed equally. *, Correspondence Jianghong An, Department of Oncology and Hematology, Third People’s Hospital of Shenzhen, The Second Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518000, China. Telephone number: 13167874626. Email: [email protected] Received: December 18, 2020; Accepted: April 13, 2022; Published online: August 2, 2022. Cite this paper: Ling Shao, Shen Qian, Jianghong An, Xiaohua Tan. (2022) Application of gut microbiomes in the diagnosis and treatment of cancer. Global Journal of Microbiology, 3(1):1-13. http://naturescholars.com/gjmic.030101. https://doi.org/10.46633/gjmic.030101. Copyright© 2022 by Scholars Publishing, LLC.
Abstract
In this study, the gut microbiome was closely related to human health. Changes in intestinal microbial composition promoted carcinogenesis and cancer development. Specific intestinal microorganisms and their metabolites regulated host physiological functions and tumor microenvironment and significantly affected the anti-tumor treatment response and its adverse effects. Gut microbiome-based strategies have shown promising prospects in the diagnosis and treatment of cancer, and many novel intestinal microbiological manipulation strategies have emerged. At the same time, there were many challenges in transforming intestinal microecology research into clinical practice.
Key words: Gut microbiome; tumor microbiome; tumor microenvironment; immunotherapy.