Review

Research Progress of Reoviruses in The Treatment of Ovarian Cancer

Jianhua Sun¹, Cunjian Yi ^1,✉

¹Department of Obstetrics and Gynecology, Jingzhou No1 People’s Hospital and First Affiliated Hospital of Yangtze University, Jingzhou, 434023, China.

✉ Correspondence
Cunjian Yi, Department of Obstetrics and Gynecology, The First Clinical Medical College of Yangtze University；Jingzhou First People's Hospital, Jingzhou 434023, Hubei, China.Email:[email protected]. Telephone number: 13339738010.
Received: October 31, 2020; Accepted: November 30, 2020; Published online: January 14, 2021.
Cite this paper: Jianhua Sun, Cunjian Yi. (2021) Research progress of reoviruses in the treatment of ovarian cancer. Global Journal of Microbiology, 2(1):17-26. https://naturescholars.com/gjmic.020102. https://doi.org/10.46633/gjmic.020102.
Copyright© 2021 by Scholars Publishing, LLC.

Abstract

Ovarian cancer is one of the most common malignant tumors in the female reproductive system. At present, the first choice of treatment is surgery, postoperative adjuvant chemotherapy and radiotherapy. However, advanced ovarian cancer is resistant to current chemotherapeutic drugs, so the treatment of advanced ovarian cancer is still facing great challenges, and there is an urgent need for new treatments. In recent years, with the development of therapeutic methods, oncolytic viruses have attracted more and more attention. Oncolytic viruses can self-replicate, target and replicate in tumor cells, selectively kill tumor cells and induce the body to produce specific anti-tumor immune response pathways to achieve targeted therapy purposes, and ultimately lead to tumor cell lysis and death. At present, the main ones discovered for clinical trials include reovirus, herpes simplex virus-1, adenovirus, vaccinia virus, Newcastle disease virus, measles virus and so on. Among them, in recent years, reoviruses have received more attention in the treatment of tumors. This article mainly reviews the research of oncolytic reoviruses in the treatment of ovarian cancer.

Key words: Oncolytic virus; Reovirus; Ovarian Cancer; Tumor Therapy.